Thursday, June 30, 2011

Mobile Phone Derived Electromagnetic Fields Can Disturb Learning and Causes Body Warming

UMTS effect investigated by  Ruhr-University Bochum (RUB) neuroscientists

High frequency non-ionizing radiation, emitted by mobile phones, is redundantly matter of discussions. The effects of high frequency electromagnetic fields (HEFs) derived from mobile phones have been discussed since the 1950's. Neuroscientists from Bochum were now able to elucidate this question. For the first time, they provide proof that extremely high-powered electromagnetic fields (EMFs) indeed influence learning processes on the synaptic level within the brain, independent from other factors like stress. "For this effect, very high values are necessary. These do not occur during the daily use of mobile phones", explains Dr. Nora Prochnow (Medical Faculty of the RUB).

Mobile phone derived non-ionizing radiation can produce heat…

HEFs are not only used in mobile phones, but also in a variety of other communication systems like radio, television or cordless telephone sets. Mobile phones of the so called third generation utilize the UMTS technology (Universal Mobile Communication System) with a frequency of 1200 MHz and a relatively weak operating range (3.8-4.8 V/m).

With increasing power, EMFs are able to elicit local warming of body tissues, being also described as a "thermal effect". Reportedly, mobile phones can cause local warming of the brain by less than 0.1°C. The effect on function and structure of the brain during long term use of mobile phones (e.g. > 30 min) remains unexplained until now.

…and might influence cellular activity

Furthermore, statements regarding the non-thermal effects of mobile phone emitted EMFs are unclear and contradictive. These comprise for instance an increase in permeability and fluidity of cellular membranes, which can be implicated in changes in ion-channel integration and metabolism, even without a detectable change in temperature. This may impair synaptic learning processes in the brain. Until now, experiments could only insufficiently enlighten, whether these effects are derived from non-thermal HEFs or from stress, like it can be induced by handling of the experimental animal (e.g. placing a rat into an unknown environment).

Stress or non-thermal EMF effect – Scientists line out for the first time

To investigate this question, a new study was performed by scientists of the Department of Neuroanatomy and Molecular Brain Research (Professor Dr. med. Rolf Dermietzel) in cooperation with the Chair of Electromagnetic Theory of the University of Wuppertal. For the experiment, rats were placed into differently powered non-thermal HEFs in the UMTS operating range. Synaptic learning and memory formation were analysed by electrophysiological methods. Furthermore, all animals were tested for stress hormone release immediately following the HEF exposure.

Mobile phone use seems to be harmless – critical values for occupational use have to be controlled precisely

The results: Although there was daily training and effortless contact to the exposure environment, increases in blood derived stress hormone levels could be detected for all exposed groups. The stress clearly influences learning and memory formation on the synaptic level in the rat brain. High powered EMFs (SAR 10 W/kg) also have a significant effect on learning and memory formation.

In contrast to this, weak EMFs (SAR 0 and 2 W/kg) lead to no detectable changes or impairments. "These results cannot directly be transferred to humans", says Nora Prochnow. "But in the animal model, it can be demonstrated that neuronal mechanisms of synaptic learning can serve as a target for high powered EMFs".

However, there is no need for serious concerns: humans are not exposed to this type of high powered EMFs during daily mobile phone use. Nevertheless, the matter has to be regarded differently in special occupational situations, for instance during the use of body worn antenna systems as it is common for security services or military purposes. Here, critical levels for occupational exposure may be reached more easily and have to be controlled carefully.

Contacts and sources:
Dr. Nora Prochnow
Ruhr-University Bochum

Major Step Forward: Genetic Alterations In Pig Tissue May Allow For Human Transplantation


New research published in the Journal of Leukocyte Biology suggests that over-expressing the human programmed death ligand-1 molecule in pig artery endothelial cells induces human immune tolerance

Bethesda, MD—A sizzling genetic discovery by Chinese scientists may one day allow pig tissue to be transplanted successfully into humans. Their research presented in the Journal of Leukocyte Biology (http://www.jleukbio.org) represents a major step forward toward filling the shortage of vital organs for human transplantation. At the core of their work, they showed that altering or overexpressing the human programmed death ligand-1 (PD-L1) molecule in the endothelial cells of pig arteries reduces the conditions that lead to rejection. This strongly suggests that humans could receive altered porcine organs with fewer complications.

"Genetically engineered pigs may someday overcome the severe donor organ shortage, and save human lives," said Qing Ding, Ph.D., co-study author from the Shanghai Institute of Immunology at the Shanghai Jiaotong University School of Medicine in Shanghai, China.

To make the discovery, scientists conducted experiments using two groups of pig vascular endothelial cells. The first group was genetically engineered to express human PD-L1, while the second group was normal. When both sets of cells were exposed to human lymphocytes, lower rejection response occurred in the group with the altered gene, while higher rejection responses were seen in the normal cells. Study results suggest that human PD-L1 could be used as a novel therapeutic agent to enhance tolerance of xenotransplants and also supports the possibility of using human PD-L1 transgenic pigs as xenotransplant donors. Using this type of genetic engineering technique could potentially overcome current challenges related to successful pig/human transplant rejection.

"Xenotransplantation has the potential to fill a huge gap between the number of available human donor tissue and number of needy recipients," said John Wherry, Ph.D., Deputy Editor of theJournal of Leukocyte Biology, "but our understanding of the pathways that might enhance the acceptance and physiological function of organs from animals such as pigs remains incomplete. The study by Dr. Ding and his colleagues is a very substantial step forward in defining a key immunoregulatory pathway that could be targeted in this setting."

Contacts and sources: 
The Journal of Leukocyte Biology (http://www.jleukbio.org) publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. TheJournal of Leukocyte Biology is published by the Society for Leukocyte Biology.

Details: Details: Qing Ding, Liming Lu, Xiaorong Zhou, Yun Zhou, and Kuang-Yen Chou. Human PD-L1-overexpressing porcine vascular endothelial cells induce functionally suppressive human CD4+CD25hiFoxp3+ Treg cells . J Leukoc Biol July 2011 90:77-86; doi:10.1189/jlb.1210691 ; http://www.jleukbio.org/content/90/1/77.abstract

10 Traditional Newspapers that Successfully Moved Online

Where, oh where, have all the newspapers gone? Since the recession, which began in 2007, newsprint newspaper circulation and advertising revenue have declined at an alarming rate. Even the largest papers have cut back significantly, in terms of resources and personnel. To meet these continuing challenges newspapers have expanded their Internet presence, some to the point of abandoning newsprint altogether, as did The Seattle Post-Intelligencer, in 2009. Listed here are some newspapers that have led the way in the transition to a digital world.


Image: Wikipedia

  • The New York Times – The New York Times, whose famous motto reads “All the news that’s fit to print”, has had a viable online presence since 1995, and, today, boasts one of the most successful multi-media programs in the world.
  • The Wall Street Journal – The nation’s most successful newspaper, in terms of circulation, The Wall Street Journal first hit the web, in 1996, with Wall Street Journal Online. Today, the paper has an integrated format, keeping it at the forefront of the journalism world.
  • USA Today – First published in hard copy in 1988, the paper ranks just behind The Wall Street Journalin overall circulation, which counts 400,000 online subscriptions in those circulation numbers. USA Todayhas used the web since 1995, and is touted for its use of social networking.
  • The Seattle Post-Intelligencer – After nearly 150 years in print, the Post-Intelligencer went to an online-only format in March, 2009, and now reaches over 200,000 people daily.
  • The Washington Post – One of America’s leading newspapers since its inception, in 1877, and noted for its political reportage, the Post put out its first online copy in1996, and today is known for the distinct differences between newsprint and online content.
  • The Denver Post – Active online, the Post offers a very interesting feature: when subscribers register with the online site, they also receive their own blog and photo gallery.
  • Annarbor.com – An example of a hybrid-news format, annarbor.com replaced the Ann Arbor News in 2009, but still publishes a twice-weekly newsprint edition.
  • Houston Chronicle – Largest of the Hearst newspapers, and one of the top-ten newspapers in national circulation (only one in the top-ten never to have won a Pulitzer Prize), the Chronicle‘s online edition is known for its innovative technology, including RSS (Really Simple Syndication), which gives almost instantaneous access to breaking news.
  • The San Francisco Chronicle – SFGate.com, which is the online branch of the Chronicle,broke new ground, in 2010, when political cartoonist Mark Fiore won a Pulitzer Prize for his series of humorous and biting videos.
  • The Minneapolis Star Tribune – Startribune.com is the online arm of the parent newsprint paper, and the web content is notable for its coverage of local and state news, which is featured, rather than national and international news. The interactive approach is quite popular in an area where people are very community-oriented.
The world continues to change, and journalism will need to continue to evolve as well.

Contacts and sources:
Story by Coleen Torres
http://www.phonetvinternet.com/insider/10-traditional-newspapers-that-successfully-moved-online/